The action at the Mbombela Stadium starts at 19h00 and the match will be broadcast live on SuperSport.
The only change in the pack of forwards is at blindside flanker, where Phumzile Maqondwana takes over from Darrien Landsberg.
At the back, the fleet-footed Devon Williams gets another run at flyhalf, in the place of Tiaan Botes, after warming the bench last weekend in Cape Town.
With Etienne Taljaard back in the mix at right wing, Luther Obi moves across and will start in the No 11 shirt, where Ruwellyn Isbell played last week.
While Isbell is out of the match 23 altogether, Landsberg and Botes have been included on the bench.
Phakisa Pumas: 15 Tapiwa Mafura, 14 Etienne Taljaard, 13 Erich Cronje, 12 Ali Mgijima, 11 Luther Obi, 10 Devon Williams, 9 Chriswill September, 8 Willie Engelbrecht, 7 Phumzile Maqondwana, 6 Daniel Maartens, 5 Pieter Jansen van Vuren (captain), 4 Le Roux Roets, 3 Ignatius Prinsloo, 2 Simon Westraadt, 1 Morgan Naude. Replacements: 16 AJ le Roux, 17 Dewald Maritz, 18 Wikus Groenewald, 19 Darrien Landsberg, 20 Ewart Potgieter, 21 Ginter Smuts, 22 Tiaan Botes, 23 Wayne van der Bank.
Match information – Phakisa Pumas v Toyota Cheetahs
Date: Friday, 18 December 2020
Venue: Mbombela Stadium, Nelspruit
Referee: Rasta Rasivhenge
Assistant Referees: Aimee Barrett-Theron, Morne Ferreira
TMO: Pro Legoete
TV: SuperSport Grandstand and Rugby