Meihuizen joins JD Schickerling in the second row for the Carling Currie Cup encounter against the Free State side, which kicks off at 16h30 on Saturday at Toyota Stadium and will be broadcast live on SuperSport.
Jaco Coetzee, a late replacement for Springbok captain Siya Kolisi last weekend, retains the No 6 jersey, next to Johan du Toit and Juarno Augustus in the loose trio.
The front row duo of Scarra Ntubeni (hooker) and Neethling Fouche (prop) are back from injury to take their places on the replacements bench, along with loose forward Marcel Theunissen.
DHL Western Province head coach John Dobson said that his team is intent on delivering an accurate performance in Bloemfontein.
"The continuity in selection this week will hopefully help us to build some momentum and play with some fluency," said Dobson.
"We know that it will take an 80-minute performance in Bloemfontein this weekend if we are to come away with the result that we are looking for."
DHL Western Province: 15 Damian Willemse, 14 Sergeal Petersen, 13 Dan du Plessis, 12 Rikus Pretorius, 11 Angelo Davids, 10 Tim Swiel, 9 Herschel Jantjies, 8 Juarno Augustus, 7 Johan du Toit, 6 Jaco Coetzee, 5 David Meihuizen, 4 JD Schickerling, 3 Frans Malherbe, 2 Bongi Mbonambi, 1 Steven Kitshoff (captain). Replacements (from): 16 Scarra Ntubeni, 17 Kwenzo Blose, 18 Neethling Fouche, 19 Chris van Zyl, 20 Marcel Theunissen, 21 Paul de Wet, 22 Ruhan Nel, 23 Tristan Leyds, 24 Leon Lyons, 25 Chad Solomon, 26 Ben-Jason Dixon.
Match Information – Toyota Cheetahs v DHL Western Province
Date: Saturday, 2 January 2021
Venue: Toyota Stadium, Bloemfontein
Referee: Stuart Berry
Assistant Referees: Griffin Colby and Egon Seconds
TMO: Marius van der Westhuizen
TV: SuperSport Grandstand and Rugby