The match at Emirates Airline Park kicks off at 16h00 and will be broadcast live on SuperSport.
Mapimpi's inclusion at left wing is one of five changes to the backline. As a result of the Springbok speedster's return, Yaw Penxe moves across to right wing in place of the injured Sbu Nkosi.
Manie Libbok will start at flyhalf Curwin Bosch at flyhalf, Werner Kok replaces Lukhanyo Am at centre and Anthony Volmink will start at fullback in place of Aphelele Fassi.
Everitt has also named an all-new front row with Ntuthuko Mchunu, Kerron van Vuuren and Wiehahn Herbst taking over from Ox Nche, Fez Mbatha and Thomas du Toit, all of whom will make an appearance later in the game off the bench.
In the second row, Hyron Andrews returns to the side in the place of Reniel Hugo, while James Venter is a welcome inclusion after a long-term injury.
Phepsi Buthelezi will play at No 8, with Thembelani Bholi named on the bench, while Henco Venter will take over the captaincy from Am.
It will be a tough ask for the Cell C Sharks at Emirates Airline Park. After losing all three of their first round matches, the Emirates Lions came back to hand the table-topping Vodacom Bulls their first defeat in the tournament in the last round.
For the Cell C Sharks, two losses in a row sits uncomfortably on the shoulders of a team that sets high standards to match their aspirations and the final two weeks offer the opportunity of ensuring the season is a successful one.
Cell C Sharks: 15 Anthony Volmink, 14 Yaw Penxe, 13 Werner Kok, 12 Marius Louw, 11 Makazole Mapimpi, 10 Manie Libbok, 9 Jaden Hendrikse, 8 Phepsi Buthelezi, 7 Henco Venter (captain), 6 James Venter, 5 Hyron Andrews, 4 JJ van der Mescht, 3 Wiehahn Herbst, 2 Kerron van Vuuren, 1 Ntuthuko Mchunu. Replacements: 16 Fez Mbatha, 17 Ox Nche, 18 Thomas du Toit, 19 Ruben van Heerden, 20 Thembelani Bholi, 21 Grant Williams, 22 Boeta Chamberlain, 23 Jeremy Ward.