The 2021 Kick-Off Pools match in the Nelson Mandela Bay Stadium is the second for both teams this season and starts at 16h45. AJ Jacobs is the referee and it will be broadcast live on SuperSport.
The trip to the east coast is an opportunity for Nkosi and Roux to give another host of young players the chance to showcase their talents.
The side is brimming with youngsters who caught the eye during the national Under-21 tournament that was held at Emirates Airline Park last year and will test the depth of the union's ranks.
The backline remains pretty much the same as the one that ran out against New Nation Pumas late last month, with Ngia Selengbe (wing, pictured above) and Dillon Smit (scrumhalf) the new starters.
Selengbe takes over from Divan Rossouw who moves to fullback in place of EW Viljoen, while Smit starts in place of Morne van den Berg, who plays off the bench.
The forwards have a much more youthful look to it.
Ruhan Straeuli, Sibusiso Sangweni and Mark Snyman are the new loose trio and all on debut, while Ruben Schoeman joins Reinhard Nothnagel in the engine room.
Dameon Venter moves from the reserves to start at hooker in place of PJ Botha. The bench comprise almost completely of youngsters, with all but Van den Berg new in the senior ranks.
Lions: 15 Divan Rossouw, 14 Prince Nkabinde, 13 Manuel Rass, 12 James Mollentze, 11 Ngia Selengbe, 10 Tiaan Swanepoel, 9 Dillon Smit, 8 Ruhan Straeuli, 7 Sibusiso Sangweni, 6 Mark Snyman, 5 Reinhard Nothnagel (captain), 4 Ruben Schoeman, 3 Wiehahn Herbst, 2 Dameon Venter, 1 Nathan McBeth. Replacements (from): 16 Morné Brandon, 17 Banele Mthenjane, 18 Asenathi Nthlabakanye, 19 Mandisi Mtiyane, 20 Izan Esterhuizen, 21 Morné van den Berg, 22 Jordan Hendrikse, 23 Luke Rossouw, 24 Sibusiso Shongwe, 25 Jarod Cairns.